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Ja znalazłem taki opis problemu, niestety po angielsku:
Setup is unable to load the installation script file.
Setup.exe is unable to load the script file into memory for processing. Setup.exe was internally unable to load the script file due to low memory conditions. On the other hand, it was unable to create its internal data structures, window classes or other control classes. The script file was contaminated or damaged, or was not compiled properly.
This error is highly unlikely. If it does occur, (1) recompile the script file, (2) reboot the machine, and (3) try running InstallShield again with the New script file.